UBXN7 docks on neddylated cullin complexes using its UIM motif and causes HIF1a accumulation.
AuthorsBandau S, Knebel A, Gage ZO, Wood NT, Alexandru G,
JournalBMC Biol
PubMed ID22537386
The proteins from the UBA-UBX family interact with ubiquitylated proteins via their UBA domain and with p97 via their UBX domain, thereby acting as substrate-binding adaptors for the p97 ATPase. In particular, human UBXN7 (also known as UBXD7) mediates p97 interaction with the transcription factor HIF1a that is actively ubiquitylated ... More
Cullin-3 regulates late endosome maturation.
AuthorsHuotari J, Meyer-Schaller N, Hubner M, Stauffer S, Katheder N, Horvath P, Mancini R, Helenius A, Peter M
JournalProc Natl Acad Sci U S A
PubMed ID22219362
Cullin-3 (Cul3) functions as a scaffolding protein in the Bric-a-brac, Tramtrack, Broad-complex (BTB)-Cul3-Rbx1 ubiquitin E3 ligase complex. Here, we report a previously undescribed role for Cul3 complexes in late endosome (LE) maturation. RNAi-mediated depletion of Cul3 results in a trafficking defect of two cargoes of the endolysosomal pathway, influenza A ... More