Regulation of opioid receptor trafficking and morphine tolerance by receptor oligomerization.
Authors He Li; Fong Jamie; von Zastrow Mark; Whistler Jennifer L;
JournalCell
PubMed ID11832216
'The utility of morphine for the treatment of chronic pain is hindered by the development of tolerance to the analgesic effects of the drug. Morphine is unique among opiates in its ability to activate the mu opioid receptor (MOR) without promoting its desensitization and endocytosis. Here we demonstrate that [D-Ala(2)-MePhe(4)-Gly(5)-ol] ... More