F-actin-dependent insolubility of chromatin-modifying components.
AuthorsAndrin C, Hendzel MJ
JournalJ Biol Chem
PubMed ID15082715
'Many complexes involved in chromatin modification are difficult to isolate and commonly found associated with nuclear matrix preparations. In this study, we examine the elution properties of chromatin-modifying components under different extraction conditions. We find that most, but not all, histone acetyltransferases and histone deacetylases predominantly partition with the nuclear ... More
Hypoxia is a modifier of SMN2 splicing and disease severity in a severe SMA mouse model.
Spinal muscular atrophy (SMA) is a progressive neurodegenerative disease associated with low levels of the essential survival motor neuron (SMN) protein. Reduced levels of SMN is due to the loss of the SMN1 gene and inefficient splicing of the SMN2 gene caused by a C>T mutation in exon 7. Global ... More