The leader protein of cardioviruses inhibits stress granule assembly.
AuthorsBorghese F, Michiels T
JournalJ Virol
PubMed ID21752908
'Stress granules (SG) are cytoplasmic aggregates of stalled translation preinitiation complexes that form in cells exposed to various environmental stresses. Here, we show that stress granules assemble in cells infected with Theiler''s murine encephalomyelitis virus (TMEV) mutants carrying alterations in the leader (L) protein, but not in cells infected with ... More
PTB deficiency causes the loss of adherens junctions in the dorsal telencephalon and leads to lethal hydrocephalus.
AuthorsShibasaki T, Tokunaga A, Sakamoto R, Sagara H, Noguchi S, Sasaoka T, Yoshida N,
JournalCereb Cortex
PubMed ID22705452
'Polypyrimidine tract-binding protein (PTB) is a well-characterized RNA-binding protein and known to be preferentially expressed in neural stem cells (NSCs) in the central nervous system; however, its role in NSCs in the developing brain remains unclear. To explore the role of PTB in embryonic NSCs in vivo, Nestin-Cre-mediated conditional Ptb ... More
The leader protein of Theiler's virus interferes with nucleocytoplasmic trafficking of cellular proteins.
AuthorsDelhaye S, van Pesch V, Michiels T,
JournalJ Virol
PubMed ID15047849
'The leader protein of Theiler''s virus was previously shown to block the production of alpha/beta interferon by infected cells. Here, we observed that expression of the leader protein in infected cells triggered subcellular redistribution of a nucleus-target green fluorescent protein. It enhanced redistribution of the nuclear polypyrimidine tract-binding protein but ... More
MicroRNA-132 loss is associated with tau exon 10 inclusion in progressive supranuclear palsy.
AuthorsSmith PY, Delay C, Girard J, Papon MA, Planel E, Sergeant N, Buée L, Hébert SS
JournalHum Mol Genet
PubMed ID21807765
Tauopathies represent a large class of neurological and movement disorders characterized by abnormal intracellular deposits of the microtubule-associated protein tau. It is now well established that mis-splicing of tau exon 10, causing an imbalance between three-repeat (3R) and four-repeat (4R) tau isoforms, can cause disease; however, the underlying mechanisms affecting ... More