In vivo gene therapy of human bladder cancer with PTEN suppresses tumor growth, downregulates phosphorylated Akt, and increases sensitivity to doxorubicin.
AuthorsTanaka M, Grossman HB,
JournalGene Ther
PubMed ID12923562
'The PTEN gene, located on chromosome 10, is a phosphatase in the phosphatidylinositol 3''-kinase (PI3''K)-mediated signal transduction pathway. PTEN inhibits the activation of Akt, a serine-threonine kinase involved in proliferative metabolic and antiapoptotic pathways, and has tumor suppressive properties. We created a PTEN adenoviral vector, Ad-MMAC, to assess the role ... More
Epigenetic and genetic alterations of PTEN in hepatocellular carcinoma.
AuthorsWang L, Wang WL, Zhang Y, Guo SP, Zhang J, Li QL,
JournalHepatol Res
PubMed ID17441812
Aim: To investigate the roles of epigenetic and genetic alterations of the phosphatase and tensin homologue on chromosome 10 gene (PTEN) in carcinogenesis and the development of hepatocellular carcinomas (HCC). Methods: A total of 56 cases of HCC tissues and six liver cell lines were studied for the expression of ... More