Hailey-Hailey disease and tight junctions: Claudins 1 and 4 are regulated by ATP2C1 gene encoding Ca(2+) /Mn(2+) ATPase SPCA1 in cultured keratinocytes.
AuthorsRaiko L, Siljamäki E, Mahoney MG, Putaala H, Suominen E, Peltonen J, Peltonen S,
JournalExp Dermatol
PubMed ID22639968
'Mutations in the ATP2C1 gene encoding Ca(2+) /Mn(2+) ATPase SPCA1 cause Hailey-Hailey disease (HHD, OMIM 16960). HHD is characterized by epidermal acantholysis. We attempted to model HHD using normal keratinocytes, in which the SPCA1 mRNA was down-regulated with the small inhibitory RNA (siRNA) method. SiRNA inhibition significantly down-regulated the SPCA1 ... More
Pathological changes of the anatomical structure and markers of the limbal stem cell niche due to inflammation.
AuthorsNubile M, Curcio C, Dua HS, Calienno R, Lanzini M, Iezzi M, Mastropasqua R, Agnifili L, Mastropasqua L,
JournalMol Vis
PubMed ID23441125
The corneoscleral limbus is the site of corneal epithelial stem cells (SC). The aim of this study is to evaluate the expression of different SC markers in the normal human limbus and to determine how this is affected by inflammation. Corneoscleral specimens from healthy and inflamed donor eyes were examined ... More
Human eccrine sweat gland cells can reconstitute a stratified epidermis.
AuthorsBiedermann T, Pontiggia L, Böttcher-Haberzeth S, Tharakan S, Braziulis E, Schiestl C, Meuli M, Reichmann E,
JournalJ Invest Dermatol
PubMed ID20376062
Eccrine sweat glands are generally considered to be a possible epidermal stem cell source. Here we compared the multilayered epithelia formed by epidermal keratinocytes and those formed by eccrine sweat gland cells. We demonstrated both in vitro and in vivo the capability of human eccrine sweat gland cells to form ... More
p38MAPK signaling and desmoglein-3 internalization are linked events in pemphigus acantholysis.
AuthorsJolly PS, Berkowitz P, Bektas M, Lee HE, Chua M, Diaz LA, Rubenstein DS,
JournalJ Biol Chem
PubMed ID20093368
Pemphigus vulgaris (PV) is an autoimmune blistering disease in which antibodies against the desmosomal cadherin, DSG3 (desmoglein-3), cause acantholysis. It has become increasingly clear that loss of cell-cell adhesion in PV is a complex and active process involving multiple signaling events such as activation of p38MAPK. It has also been ... More