Claudins create charge-selective channels in the paracellular pathway between epithelial cells.
AuthorsColegio OR, Van Itallie CM, McCrea HJ, Rahner C, Anderson JM,
JournalAm J Physiol Cell Physiol
PubMed ID12055082
Epithelia separate tissue spaces by regulating the passage of ions, solutes, and water through both the transcellular and paracellular pathways. Paracellular permeability is defined by intercellular tight junctions, which vary widely among tissues with respect to solute flux, electrical resistance, and ionic charge selectivity. To test the hypothesis that members ... More
Minimal effects of VEGF and anti-VEGF drugs on the permeability or selectivity of RPE tight junctions.
AuthorsPeng S, Adelman RA, Rizzolo LJ,
JournalInvest Ophthalmol Vis Sci
PubMed ID20042644
Bevacizumab and ranibizumab are currently used to treat age-related macular degeneration by neutralizing vascular endothelial growth factor (VEGF). In this study, the potential side effects on the outer blood-retinal barrier were examined. Human fetal RPE (hfRPE) cells were used because they are highly differentiated in culture. The claudin composition of ... More