Interleukin-6 deficiency reduces the brain inflammatory response and increases oxidative stress and neurodegeneration after kainic acid-induced seizures.
AuthorsPenkowa M, Molinero A, Carrasco J, Hidalgo J,
JournalNeuroscience
PubMed ID11182244
'The role of interleukin-6 in hippocampal tissue damage after injection with kainic acid, a rigid glutamate analogue inducing epileptic seizures, has been studied by means of interleukin-6 null mice. At 35mg/kg, kainic acid induced convulsions in both control (75%) and interleukin-6 null (100%) mice, and caused a significant mortality (62%) ... More
A Domain in TNF Receptors That Mediates Ligand-Independent Receptor Assembly and Signaling
Authors Francis Ka-Ming Chan, Hyung J. Chun, Lixin Zheng, Richard M. Siegel, Kimmie L. Bui, * Michael J. Lenardo
JournalScience
PubMed ID10875917
A conserved domain in the extracellular region of the 60- and 80-kilodalton tumor necrosis factor receptors (TNFRs) was identified that mediates specific ligand-independent assembly of receptor trimers. This pre-ligand-binding assembly domain (PLAD) is physically distinct from the domain that forms the major contacts with ligand, but is necessary and ... More
Neutrophils promote aerogenous spread of lung adenocarcinoma with bronchioloalveolar carcinoma features.
AuthorsWislez M, Antoine M, Rabbe N, Gounant V, Poulot V, Lavolé A, Fleury-Feith J, Cadranel J,
JournalClin Cancer Res
PubMed ID17575214
Adenocarcinoma with bronchioloalveolar carcinoma (BAC) features is a subtype of non-small cell lung cancers characterized by an intense inflammatory reaction composed of macrophages and neutrophils and by a distinct natural history with intrapulmonary spread leading to death due to respiratory failure. We hypothesized that neutrophils could promote aerogenous spread of ... More