Binding of calmodulin to the D2-dopamine receptor reduces receptor signaling by arresting the G protein activation switch.
AuthorsBofill-Cardona E, Kudlacek O, Yang Q, Ahorn H, Freissmuth M, Nanoff C
JournalJ Biol Chem
PubMed ID10926927
Signaling by D(2)-dopamine receptors in neurons likely proceeds in the presence of Ca(2+) oscillations. We describe here the biochemical basis for a cross-talk between intracellular Ca(2+) and the D(2) receptor. By activation of calmodulin (CaM), Ca(2+) directly inhibits the D(2) receptor; this conclusion is based on the following observations: (i) ... More