Inflammatory bowel diseases (IBD)--Crohn's disease and ulcerative colitis--are relapsing chronic inflammatory disorders which involve genetic, immunological, and environmental factors. The regulation of TNF-alpha, a key mediator in the inflammatory process in IBD, is interconnected with mitogen-activated protein kinase pathways. The aim of this study was to characterize the activity and ... More
Stress kinase phosphorylation is increased in pacing-induced heart failure in rabbits.
AuthorsSchulz R, Aker S, Belosjorow S, Konietzka I, Rauen U, Heusch G,
JournalAm J Physiol Heart Circ Physiol
PubMed ID12842818
In hearts with chronic left ventricular (LV) systolic dysfunction secondary to hypertension or myocardial infarction, MAPK phosphorylation and/or activity are increased. Whether other settings of LV dysfunction not associated with ischemia-reperfusion are also characterized by increased MAPK phosphorylation or activity is unknown. After 3 wk of rapid LV pacing (400 ... More