'Recent studies have shown that mechanical forces on airway epithelial cells can induce upregulation of genes involved in airway remodeling in diseases such as asthma. However, the relevance of these responses to airway wall remodeling is still unclear since 1). mechanotransduction is highly dependent on environment (e.g., matrix and other ... More
Identification of PKCzetaII: an endogenous inhibitor of cell polarity.
AuthorsParkinson SJ, Le Good JA, Whelan RD, Whitehead P, Parker PJ
JournalEMBO J
PubMed ID14685273
A new member of the atypical protein kinase C (aPKC) family, designated PKCzetaII, is identified in this study. The gene contains no introns and is 98% homologous with the cDNA encoding PKCzeta. The PKCzetaII coding region is frame-shifted with respect to the PKCzeta open reading frame, resulting in expression of ... More
Role of megalin (gp330) in transcytosis of thyroglobulin by thyroid cells. A novel function in the control of thyroid hormone release.
AuthorsMarinò M, Zheng G, Chiovato L, Pinchera A, Brown D, Andrews D, McCluskey RT
JournalJ Biol Chem
PubMed ID10702280
When thyroglobulin (Tg) is endocytosed by thyrocytes and transported to lysosomes, thyroid hormones (T4 and T3) are released. However, some internalized Tg is transcytosed intact into the bloodstream, thereby avoiding proteolytic cleavage. Here we show that megalin (gp330), a Tg receptor on thyroid cells, plays a role in Tg transcytosis. ... More