Effect of the secretory small GTPase Rab27B on breast cancer growth, invasion, and metastasis.
AuthorsHendrix A, Maynard D, Pauwels P, Braems G, Denys H, Van den Broecke R, Lambert J, Van Belle S, Cocquyt V, Gespach C, Bracke M, Seabra MC, Gahl WA, De Wever O, Westbroek W,
JournalJ Natl Cancer Inst
PubMed ID20484105
BACKGROUND Secretory GTPases like Rab27B control vesicle exocytosis and deliver critical proinvasive growth regulators into the tumor microenvironment. The expression and role of Rab27B in breast cancer were unknown. METHODS Expression of green fluorescent protein (GFP) fused with wild-type Rab3D, Rab27A, or Rab27B, or Rab27B point mutants defective in GTP/GDP ... More
The effect of Longan seed polyphenols on colorectal carcinoma cells.
AuthorsChung YC, Lin CC, Chou CC, Hsu CP,
JournalEur J Clin Invest
PubMed ID20561027
'Polyphenol-rich longan seed extract (LSP) is a free radical scavenger and antioxidant. However, the effect of LSP on the growth of human colorectal carcinoma cells (CRC) has not yet been evaluated. Polyphenols of longan seeds were extracted and measured by colorimetry. Four CRC cell lines (Colo 320DM, SW480, HT-29 and ... More
Histone H4 post-translational modifications in chordate mitotic and endoreduplicative cell cycles.
AuthorsSpada F, Chioda M, Thompson EM,
JournalJ Cell Biochem
PubMed ID15937898
Histone post-translational modifications mark distinct structural and functional chromatin states but little is known of their involvement in the progression of different cell cycle types across phylogeny. We compared temporal and spatial dynamics of histone H4 post-translational modifications during both mitotic and endoreduplicative cycles of the urochordate, Oikopleura dioica, and ... More