Axon regeneration in young adult mice lacking Nogo-A/B.
AuthorsKim JE, Li S, GrandPré T, Qiu D, Strittmatter SM,
JournalNeuron
PubMed ID12718854
After injury, axons of the adult mammalian brain and spinal cord exhibit little regeneration. It has been suggested that axon growth inhibitors, such as myelin-derived Nogo, prevent CNS axon repair. To investigate this hypothesis, we analyzed mice with a nogo mutation that eliminates Nogo-A/B expression. These mice are viable and ... More