Functional heterotypic interactions between astrocyte and oligodendrocyte connexins.
AuthorsMagnotti LM, Goodenough DA, Paul DL
JournalGlia
PubMed ID21046554
'Human genetic diseases and mouse knockouts illustrate that the maintenance of central nervous system myelin requires connexin expression by both astrocytes and oligodendrocytes. Because these cell types express nonoverlapping sets of connexins, the intercellular channels formed between them must be asymmetric with regard to connexin content, defined as heterotypic. Here, ... More
Distinct and gradient distributions of connexin26 and connexin30 in the cochlear sensory epithelium of guinea pigs.
AuthorsZhao HB, Yu N
JournalJ Comp Neurol
PubMed ID16998915
'Connexin26 (Cx26) and Cx30 are predominant isoforms of gap junction channels in the cochlea and play a critical role in hearing. In this study, the cellular distributions of Cx26 and Cx30 in the cochlear sensory epithelium of guinea pigs were examined by immunofluorescent staining and confocal microscopy in whole mounts ... More
The relationship between connexins, gap junctions, tissue architecture and tumour invasion, as studied in a novel in vitro model of HPV-16-associated cervical cancer progression.
AuthorsAasen T, Hodgins MB, Edward M, Graham SV,
JournalOncogene
PubMed ID12970745
Disruption of gap junctional intercellular communication (GJIC) and/or connexins (gap junction proteins) is frequently reported in malignant cell lines and tumours. Certain human papillomaviruses (HPV) associated with the development of cancers, especially of the cervix, have previously been reported to downregulate GJIC in vitro. There is also evidence for reduced ... More
Localization of connexin26 and connexin32 in putative CO(2)-chemosensitive brainstem regions in rat.
Recent studies have suggested that cell-to-cell coupling, which occurs via gap junctions, may play a role in CO(2) chemoreception. Here, we used immunoblot and immunohistochemical analyses to investigate the presence, distribution, and cellular localization of the gap junction proteins connexin26 (Cx26) and connexin32 (Cx32) in putative CO(2)-chemosensitive brainstem regions in ... More