Elevated hyaluronan production induces mesenchymal and transformed properties in epithelial cells.
AuthorsZoltan-Jones A, Huang L, Ghatak S, Toole BP,
JournalJ Biol Chem
PubMed ID12954618
'During carcinoma progression, tumor cells often undergo changes similar (but not identical) to epithelialmesenchymal transitions in embryonic development. In this study, we demonstrate that experimental stimulation of hyaluronan synthesis in normal epithelial cells is sufficient to induce mesenchymal and transformed characteristics. Using recombinant adenoviral expression of hyaluronan synthase-2, we show ... More