Immortalized fibroblasts from NF-kappaB RelA knockout mice show phenotypic heterogeneity and maintain increased sensitivity to tumor necrosis factor alpha after transformation by v-Ras.
AuthorsGapuzan ME, Schmah O, Pollock AD, Hoffmann A, Gilmore TD,
JournalOncogene
PubMed ID16027734
Activation of the NF-kappaB pathway can either promote or block apoptosis and oncogenesis in different cell types and circumstances. In this report, we show that independently derived immortalized mouse embryonic fibroblast cell lines prepared from RelA knockout mice have different phenotypes, based on their sensitivity to tumor necrosis factor alpha ... More
Melanoma cell migration to type IV collagen requires activation of NF-kappaB.
AuthorsHodgson L, Henderson AJ, Dong C,
JournalOncogene
PubMed ID12527912
Chemotaxis is the consequence of environmental factors engaging their receptors to initiate signaling cascades. However, the biochemical mechanisms controlling this phenomenon are not clear. We employed an in vitro modified Boyden 48-well chemotaxis migration system to characterize the role of signal transducers in type IV collagen (CIV) induced A2058 human ... More