Interferon-gamma interferes with transforming growth factor-beta signaling through direct interaction of YB-1 with Smad3.
AuthorsHigashi K, Inagaki Y, Fujimori K, Nakao A, Kaneko H, Nakatsuka I,
JournalJ Biol Chem
PubMed ID12917425
'Transforming growth factor-beta (TGF-beta) and interferon-gamma (IFN-gamma) exert antagonistic effects on collagen synthesis in human dermal fibroblasts. We have recently shown that Y box-binding protein YB-1 mediates the inhibitory effects of IFN-gamma on alpha2(I) procollagen gene (COL1A2) transcription through the IFN-gamma response element located between -161 and -150. Here we ... More