Reduced FHIT Expression Is Associated with Mismatch Repair Deficient and High CpG Island Methylator Phenotype Colorectal Cancer.
AuthorsAl-Temaimi RA, Jacob S, Al-Ali W, Thomas DA, Al-Mulla F,
Journal
PubMed ID23797051
'Colorectal cancer (CRC) is a heterogeneous disease and a major contributor to world cancer mortality rates. Molecular subtypes of CRC have become standards for CRC classification and have established prognostic potential. Here, we attempt to corroborate and provide further insight pertinent to the fragile histidine triad (FHIT) gene in microsatellite ... More
Uncertainty in the utility of immunohistochemistry in mismatch repair protein expression in epithelial ovarian cancer.
AuthorsCoppola D, Nicosia SV, Doty A, Sellers TA, Lee JH, Fulp J, Thompson Z, Galeb S, McLaughlin J, Narod SA, Schildkraut J, Pal T,
JournalAnticancer Res
PubMed ID23155266
Utility of immunohistochemistry (IHC) for mismatch repair (MMR) protein expression has been demonstrated in colorectal cancer but remains incompletely defined in ovarian cancer. We evaluated MMR protein expression in three population-based samples of epithelial ovarian cancers. IHC staining was performed on full-section (FS) or tissue microarray (TMA) slides for MLH1, ... More