The ammonium transporter RhBG: requirement of a tyrosine-based signal and ankyrin-G for basolateral targeting and membrane anchorage in polarized kidney epithelial cells.
AuthorsLopez C, Métral S, Eladari D, Drevensek S, Gane P, Chambrey R, Bennett V, Cartron JP, Le Van Kim C, Colin Y,
JournalJ Biol Chem
PubMed ID15611082
'RhBG is a nonerythroid member of the Rhesus (Rh) protein family, mainly expressed in the kidney and belonging to the Amt/Mep/Rh superfamily of ammonium transporters. The epithelial expression of renal RhBG is restricted to the basolateral membrane of the connecting tubule and collecting duct cells. We report here that sorting ... More
Structural requirements for interaction of sodium channel beta 1 subunits with ankyrin.
AuthorsMalhotra JD, Koopmann MC, Kazen-Gillespie KA, Fettman N, Hortsch M, Isom LL,
JournalJ Biol Chem
PubMed ID11997395
'Sodium channel beta subunits modulate channel kinetic properties and cell surface expression levels and function as cell adhesion molecules. beta 1 and beta 2 participate in homophilic cell adhesion resulting in ankyrin recruitment to cell contact sites. We hypothesized that a tyrosine residue in the cytoplasmic domain of beta 1 ... More
Voltage-gated sodium channels confer excitability to human odontoblasts: possible role in tooth pain transmission.
'Odontoblasts are responsible for the dentin formation. They are suspected to play a role in tooth pain transmission as sensor cells because of their close relationship with nerve, but this role has never been evidenced. We demonstrate here that human odontoblasts in vitro produce voltage-gated tetrodotoxin-sensitive Na(+) currents in response ... More
Oligodendroglial modulation of fast axonal transport in a mouse model of hereditary spastic paraplegia.
AuthorsEdgar JM, McLaughlin M, Yool D, Zhang SC, Fowler JH, Montague P, Barrie JA, McCulloch MC, Duncan ID, Garbern J, Nave KA, Griffiths IR,
JournalJ Cell Biol
PubMed ID15226307
Oligodendrocytes are critical for the development of the plasma membrane and cytoskeleton of the axon. In this paper, we show that fast axonal transport is also dependent on the oligodendrocyte. Using a mouse model of hereditary spastic paraplegia type 2 due to a null mutation of the myelin Plp gene, ... More
Contactin-1 regulates myelination and nodal/paranodal domain organization in the central nervous system.
AuthorsÇolakoglu G, Bergstrom-Tyrberg U, Berglund EO, Ranscht B,
Journal
PubMed ID24385581
Myelin, a multilayered membrane sheath formed by oligodendrocytes around axons in the CNS, enables rapid nerve impulse conduction and sustains neuronal health. The signals exchanged between axons and oligodendrocytes in myelin remain to be fully elucidated. Here we provide genetic evidence for multiple and critical functions of Contactin-1 in central ... More
Essential role of oligodendrocytes in the formation and maintenance of central nervous system nodal regions.
AuthorsMathis C, Denisenko-Nehrbass N, Girault JA, Borrelli E,
JournalDevelopment
PubMed ID11731467
The membrane of myelinated axons is divided into functionally distinct domains characterized by the enrichment of specific proteins. The mechanisms responsible for this organization have not been fully identified. To further address the role of oligodendrocytes in the functional segmentation of the axolemma in vivo, the distribution of nodal (Na(+) ... More
ELF a beta-spectrin is a neuronal precursor cell marker in developing mammalian brain; structure and organization of the elf/beta-G spectrin gene.
AuthorsTang Y, Katuri V, Iqbal S, Narayan T, Wang Z, Lu RS, Mishra L, Mishra B
JournalOncogene
PubMed ID12149647
Spectrins play a pivotal role in axonal transport, neurite extension, the organization of synaptic vesicles, as well as for protein sorting in the Golgi apparatus and cell membrane. Among spectrins there is great variability in sequence composition, tissue distribution, and function, with two known genes encoding the alpha-chain, and at ... More