Apical localization of a functional TRPC3/TRPC6-Ca2+-signaling complex in polarized epithelial cells. Role in apical Ca2+ influx.
AuthorsBandyopadhyay BC, Swaim WD, Liu X, Redman RS, Patterson RL, Ambudkar IS
JournalJ Biol Chem
PubMed ID15623527
Receptor-coupled [Ca2+]i increase is initiated in the apical region of epithelial cells and has been associated with apically localized Ca2+-signaling proteins. However, localization of Ca2+ channels that are regulated by such Ca2+-signaling events has not yet been established. This study examines the localization of TRPC channels in polarized epithelial cells ... More