Conditional targeting of E-cadherin in skin: insights into hyperproliferative and degenerative responses.
AuthorsTinkle CL, Lechler T, Pasolli HA, Fuchs E,
JournalProc Natl Acad Sci U S A
PubMed ID14704278
'Loss of E-cadherin has been associated with human cancers, and yet in the early mouse embryo and the lactating mammary gland, the E-cadherin null state results in tissue dysfunction and cell death. Here we targeted loss of E-cadherin in skin epithelium. The epidermal basal layer responded by elevating P-cadherin, enabling ... More
Regulation of cell-cell interactions by phosphatidic acid phosphatase 2b/VCIP.
AuthorsHumtsoe JO, Feng S, Thakker GD, Yang J, Hong J, Wary KK,
JournalEMBO J
PubMed ID12660161
We identified vascular endothelial growth factor and type I collagen inducible protein (VCIP), also known as phosphatidic acid phosphatase 2b (PAP2b), in a functional assay of angiogenesis. VCIP/PAP2b exhibits an Arg-Gly-Asp (RGD) cell adhesion sequence. Immunoprecipitation and fluorescence-activated cell sorting analyses demonstrated that VCIP-RGD is exposed to the outside of ... More