Antipsychotic drugs suppress the AKT/NF-?B pathway and regulate the differentiation of T-cell subsets.
AuthorsChen ML, Tsai TC, Lin YY, Tsai YM, Wang LK, Lee MC, Tsai FM,
JournalImmunol Lett
PubMed ID21763349
Antipsychotic drugs (APDs) are commonly used to ease the symptoms of schizophrenia; however, these same drugs also have an effect on the human immune system. Our previous studies have shown that risperidone and clozapine effectively decrease the production of IFN-? for CD4(+) T-cells in PBMC. In contrast, haloperidol causes an ... More