Natural IgG autoantibodies are abundant and ubiquitous in human sera, and their number is influenced by age, gender, and disease.
AuthorsNagele EP, Han M, Acharya NK, DeMarshall C, Kosciuk MC, Nagele RG
JournalPLoS One
PubMed ID23589757
The presence of self-reactive IgG autoantibodies in human sera is largely thought to represent a breakdown in central tolerance and is typically regarded as a harbinger of autoimmune pathology. In the present study, immune-response profiling of human serum from 166 individuals via human protein microarrays demonstrates that IgG autoantibodies are ... More