UBXN7 docks on neddylated cullin complexes using its UIM motif and causes HIF1a accumulation.
AuthorsBandau S, Knebel A, Gage ZO, Wood NT, Alexandru G,
JournalBMC Biol
PubMed ID22537386
The proteins from the UBA-UBX family interact with ubiquitylated proteins via their UBA domain and with p97 via their UBX domain, thereby acting as substrate-binding adaptors for the p97 ATPase. In particular, human UBXN7 (also known as UBXD7) mediates p97 interaction with the transcription factor HIF1a that is actively ubiquitylated ... More