Cdh1/Hct1-APC is essential for the survival of postmitotic neurons.
AuthorsAlmeida A, Bolaños JP, Moreno S,
JournalJ Neurosci
PubMed ID16148219
Cell division at the end of mitosis and G1 is controlled by Cdh1/Hct1, an activator of the E3-ubiquitin ligase anaphase-promoting complex (APC) that promotes the ubiquitylation and degradation of mitotic cyclins and other substrates. Cdh1-APC is active in postmitotic neurons, where it regulates axonal growth and patterning in the developing ... More