Cullin 3 promotes proteasomal degradation of the topoisomerase I-DNA covalent complex.
AuthorsZhang HF, Tomida A, Koshimizu R, Ogiso Y, Lei S, Tsuruo T,
JournalCancer Res
PubMed ID14871846
'DNA topoisomerase I (TOP1)-DNA covalent complexes are the initial lesions produced by antitumor camptothecins (CPTs). The TOP1-directed drugs stimulate degradation of TOP1 via the ubiquitin-proteasome pathway. We found that proteasome inhibition prevents degradation of DNA-bound TOP1 and sustains high levels of covalent complexes, thus enhancing CPT-induced cell death. Consistent with ... More