Inactivation of annexin II tetramer by S-nitrosoglutathione.
AuthorsLiu L, Enright E, Sun P, Tsai SY, Mehta P, Beckman DL, Terrian DM,
JournalEur J Biochem
PubMed ID12199706
'We investigated the effect of nitric oxide (NO) donors on the activities of annexin II tetramer (AIIt), a member of the Ca2+- dependent phospholipid-binding protein family. Incubation of purified AIIt with S-nitrosoglutathione (GSNO) led to the inhibition of AIIt-mediated liposome aggregation. This effect was dose-dependent with an IC50 of approximately ... More
An annexin 2 phosphorylation switch mediates p11-dependent translocation of annexin 2 to the cell surface.
AuthorsDeora AB, Kreitzer G, Jacovina AT, Hajjar KA,
JournalJ Biol Chem
PubMed ID15302870
Annexin 2 is a profibrinolytic co-receptor for plasminogen and tissue plasminogen activator that stimulates activation of the major fibrinolysin, plasmin, at cell surfaces. In human subjects, overexpression of annexin 2 in acute promyelocytic leukemia leads to a bleeding diathesis reflective of excessive cell surface annexin 2-dependent generation of plasmin (Menell, ... More
Annexin II mediates plasminogen-dependent matrix invasion by human monocytes: enhanced expression by macrophages.
AuthorsBrownstein C, Deora AB, Jacovina AT, Weintraub R, Gertler M, Khan KM, Falcone DJ, Hajjar KA,
JournalBlood
PubMed ID14504107
Monocytes and macrophages participate in a wide variety of host defense mechanisms. Annexin II, a fibrinolytic receptor, binds plasminogen and tissue plasminogen activator (t-PA) independently at the cell surface, thereby enhancing the catalytic efficiency of plasmin production. We demonstrated previously that annexin II on the surface of both cultured monocytoid ... More
Integrin alphaMbeta2 orchestrates and accelerates plasminogen activation and fibrinolysis by neutrophils.
AuthorsPluskota E, Soloviev DA, Bdeir K, Cines DB, Plow EF,
JournalJ Biol Chem
PubMed ID14769799
Plasmin, the pivotal thrombolytic enzyme, is generated on the surface of many cell types, where urokinase receptor (uPAR)-bound urokinase (uPA) activates cell-bound plasminogen (Plg). It has been reported that neutrophils mediate endogenous thrombolysis involving a uPA-dependent mechanism, and we previously demonstrated that both uPAR and integrin alpha(M)beta(2) recognize uPA to ... More