Multi-photon imaging of tumor cell invasion in an orthotopic mouse model of oral squamous cell carcinoma.
AuthorsGatesman Ammer A, Hayes KE, Martin KH, Zhang L, Spirou GA, Weed SA,
JournalJ Vis Exp
PubMed ID21808230
'Loco-regional invasion of head and neck cancer is linked to metastatic risk and presents a difficult challenge in designing and implementing patient management strategies. Orthotopic mouse models of oral cancer have been developed to facilitate the study of factors that impact invasion and serve as model system for evaluating anti-tumor ... More
Resveratrol blocks interleukin-18-EMMPRIN cross-regulation and smooth muscle cell migration.
AuthorsVenkatesan B, Valente AJ, Reddy VS, Siwik DA, Chandrasekar B,
JournalAm J Physiol Heart Circ Physiol
PubMed ID19561311
'Vascular smooth muscle cell (SMC) migration is an important mechanism in atherogenesis and postangioplasty arterial remodeling. Previously, we demonstrated that the proinflammatory cytokine interleukin (IL)-18 is a potent inducer of SMC migration. Since extracellular matrix metalloproteinase inducer (EMMPRIN) stimulates ECM degradation and facilitates cell migration, we investigated whether IL-18 and ... More
High extracellular matrix metalloproteinase inducer/CD147 expression is strongly and independently associated with poor prognosis in colorectal cancer.
AuthorsStenzinger A, Wittschieber D, von Winterfeld M, Goeppert B, Kamphues C, Weichert W, Dietel M, Rabien A, Klauschen F,
JournalHum Pathol
PubMed ID22417846
As in most solid tumors, colorectal cancer prognosis strongly depends on the extent of local invasion and lymph node and distant metastases. Extracellular matrix metalloproteinase inducer (EMMPRIN) is a transmembrane glycoprotein that activates matrix metalloproteinases, a group of enzymes that play an important role in tumor invasion and metastasis formation. ... More