Functional heterotypic interactions between astrocyte and oligodendrocyte connexins.
AuthorsMagnotti LM, Goodenough DA, Paul DL
JournalGlia
PubMed ID21046554
'Human genetic diseases and mouse knockouts illustrate that the maintenance of central nervous system myelin requires connexin expression by both astrocytes and oligodendrocytes. Because these cell types express nonoverlapping sets of connexins, the intercellular channels formed between them must be asymmetric with regard to connexin content, defined as heterotypic. Here, ... More
Inhibition of Mist1 homodimer formation induces pancreatic acinar-to-ductal metaplasia.
AuthorsZhu L, Tran T, Rukstalis JM, Sun P, Damsz B, Konieczny SF
JournalMol Cell Biol
PubMed ID15024058
'The pancreas consists of three main cell lineages (endocrine, exocrine, and duct) that develop from common primitive foregut precursors. The transcriptional network responsible for endocrine cell development has been studied extensively, but much less is known about the transcription factors that maintain the exocrine and duct cell lineages. One transcription ... More
Coupling of astrocyte connexins Cx26, Cx30, Cx43 to oligodendrocyte Cx29, Cx32, Cx47: Implications from normal and connexin32 knockout mice.
AuthorsNagy JI, Ionescu AV, Lynn BD, Rash JE,
JournalGlia
PubMed ID14603462
Oligodendrocytes in vivo form heterologous gap junctions with astrocytes. These oligodendrocyte/astrocyte (A/O) gap junctions contain multiple connexins (Cx), including Cx26, Cx30, and Cx43 on the astrocyte side, and Cx32, Cx29, and Cx47 on the oligodendrocyte side. We investigated connexin associations at A/O gap junctions on oligodendrocytes in normal and Cx32 ... More
Connexin expression and gap junctional coupling in human cumulus cells: contribution to embryo quality.
Gap junctional coupling among cumulus cells is important for oogenesis since its deficiency in mice leads to impaired folliculogenesis. Multiple connexins (Cx), the subunits of gap junction channels, have been found within ovarian follicles in several species but little is known about the connexins in human follicles. The aim of ... More