Epstein-Barr virus activates beta-catenin in type III latently infected B lymphocyte lines: association with deubiquitinating enzymes.
AuthorsShackelford J, Maier C, Pagano JS,
JournalProc Natl Acad Sci U S A
PubMed ID14663138
'beta-Catenin is a multifunctional protein, stabilization of which is a critical step in its functional activity. Stabilization can be conferred through several means, including mutations in beta-catenin, common in many carcinomas. In this article, we explore the effect of viral infection on the beta-catenin signaling pathway in B lymphocytes, including ... More
Reduced expression of Axin correlates with tumour progression of oesophageal squamous cell carcinoma.
AuthorsNakajima M, Fukuchi M, Miyazaki T, Masuda N, Kato H, Kuwano H,
JournalBr J Cancer
PubMed ID12771989
'Axin is a negative regulator of the Wnt signalling pathway, and genetic alterations of AXIN1 have been suggested to be an important factor of carcinogenesis in some tumours. The objective of this study was to clarify the clinicopathologic and prognostic significance of Axin in oesophageal squamous cell carcinoma (SCC). Immunohistochemical ... More
Frequent loss of the AXIN1 locus but absence of AXIN1 gene mutations in adenocarcinomas of the gastro-oesophageal junction with nuclear beta-catenin expression.
AuthorsKoppert LB, van der Velden AW, van de Wetering M, Abbou M, van den Ouweland AM, Tilanus HW, Wijnhoven BP, Dinjens WN,
JournalBr J Cancer
PubMed ID14970870
Up to 60% of gastro-oesophageal junction (GEJ) adenocarcinomas show nuclear beta-catenin expression, pointing to activated T-cell factor (TCF)/beta-catenin-driven gene transcription. We demonstrate in five human GEJ adenocarcinoma cell lines that nuclear beta-catenin expression indeed correlates with enhanced TCF-mediated transcription of a reporter gene. In several tumour types, TCF/beta-catenin activation is ... More
Nuclear-cytoplasmic shuttling of Axin regulates subcellular localization of beta-catenin.
AuthorsCong F, Varmus H,
JournalProc Natl Acad Sci U S A
PubMed ID14981260
Wnt signaling regulates many aspects of development by increasing the signaling activity of beta-catenin. Axin is a negative regulator of the Wnt signaling pathway, and it is responsible for the formation of the beta-catenin degradation complex. Genetic studies with Drosophila suggest that Axin promotes cytoplasmic localization of beta-catenin independent of ... More