The EphA4 receptor regulates neuronal morphology through SPAR-mediated inactivation of Rap GTPases.
AuthorsRichter M, Murai KK, Bourgin C, Pak DT, Pasquale EB,
JournalJ Neurosci
PubMed ID18094260
Eph receptors play critical roles in the establishment and remodeling of neuronal connections, but the signaling pathways involved are not fully understood. We have identified a novel interaction between the C terminus of the EphA4 receptor and the PDZ domain of the GTPase-activating protein spine-associated RapGAP (SPAR). In neuronal cells, ... More