NPM-ALK inhibits the p53 tumor suppressor pathway in an MDM2 and JNK-dependent manner.
AuthorsCui YX, Kerby A, McDuff FK, Ye H, Turner SD,
JournalBlood
PubMed ID19286999
Anaplastic large cell lymphoma (ALCL) is characterized by the presence of the t(2;5)(p23;q35) generating the nucleophosmin-anaplastic lymphoma kinase (NPM-ALK) fusion protein, a hyperactive kinase with transforming properties. Among these properties is the ability to regulate activity of the p53 tumor suppressor protein. In many human cancers, p53 is inactivated by ... More