Differential membrane proteomics using 18O-labeling to identify biomarkers for cholangiocarcinoma.
AuthorsKristiansen TZ, Harsha HC, Grønborg M, Maitra A, Pandey A,
JournalJ Proteome Res
PubMed ID18839982
'Quantitative proteomic methodologies allow profiling of hundreds to thousands of proteins in a high-throughput fashion. This approach is increasingly applied to cancer biomarker discovery to identify proteins that are differentially regulated in cancers. Fractionation of protein samples based on enrichment of cellular subproteomes prior to mass spectrometric analysis can provide ... More