Unique Alzheimer's disease paired helical filament specific epitopes involve double phosphorylation at specific sites.
AuthorsHoffmann R, Lee VM, Leight S, Varga I, Otvos L,
JournalBiochemistry
PubMed ID9201960
Alzheimer's disease (AD) paired helical filaments (PHFs), building blocks of neurofibrillary tangles (NFTs) are composed of hyperphosphorylated forms of the microtubule-associated protein tau (i.e., PHF-tau). Currently, much effort is devoted to the development of diagnostic antibodies specific for PHF-tau since elevated tau levels are found in the cerebral spinal fluid ... More