T-cell immune function in tumor, skin, and peripheral blood of advanced stage melanoma patients: implications for immunotherapy.
AuthorsTjin EP, Konijnenberg D, Krebbers G, Mallo H, Drijfhout JW, Franken KL, van der Horst CM, Bos JD, Nieweg OE, Kroon BB, Haanen JB, Melief CJ, Vyth-Dreese FA, Luiten RM
JournalClin Cancer Res
PubMed ID21750202
'To predict the potential antitumor effect of antigen-specific T cells in melanoma patients, we investigated T-cell effector function in relation to tumor-escape mechanisms.'
Immunophenotyping of melanomas for tyrosinase: implications for vaccine development.
AuthorsChen YT, Stockert E, Tsang S, Coplan KA, Old LJ,
JournalProc Natl Acad Sci U S A
PubMed ID7667256
Tyrosinase (EC 1.14.18.1), the key enzyme in melanin synthesis, has been shown to be one of the targets for cytotoxic T-cell recognition in melanoma patients. To develop serological reagents useful for immunophenotyping melanoma for tyrosinase, human tyrosinase cDNA was expressed in an Escherichia coli expression vector. The purified recombinant tyrosinase ... More
Cultivation-dependent plasticity of melanoma phenotype.
AuthorsKodet O, Dvoránková B, Krejcí E, Szabo P, Dvorák P, Štork J, Krajsová I, Dundr P, Smetana K, Lacina L,
Journal
PubMed ID23757003
Malignant melanoma is a highly aggressive tumor with increasing incidence and high mortality. The importance of immunohistochemistry in diagnosis of the primary tumor and in early identification of metastases in lymphatic nodes is enormous; however melanoma phenotype is frequently variable and thus several markers must be employed simultaneously. The purposes ... More