'Exosomes are nano-sized vesicles of endocytic origin that are involved in cell-to-cell communication including shuttle RNA, mainly mRNA and microRNA. As exosomes naturally carry RNA between cells, these particles might be useful in gene cancer therapy to deliver therapeutic short interfering RNA (siRNA) to the target cells. Despite the promise ... More
[Human RAD51 recombinase: the role in the cell cycle checkpoint and cellular survival].
AuthorsShtam TA, Varfolomeeva IIu, Semenova EV, Filatov MV,
JournalTsitologiia
PubMed ID19140342
The RAD51 protein, an eukaryotic homologue of Escherichia coli RecA, plays a central role in both mitotic and meiotic homologous recombination. Here, we demonstrate that short-term silencing of Rad51 gene by specific small interfering (si) RNA induces cell death of the most part of investigated cancer cell lines and normal ... More