Altered expression of junctional adhesion molecule 4 in injured podocytes.
AuthorsHarita Y, Miyauchi N, Karasawa T, Suzuki K, Han GD, Koike H, Igarashi T, Shimizu F, Kawachi H,
JournalAm J Physiol Renal Physiol
PubMed ID16118391
'Recent investigations have revealed the importance of glomerular podocytes with its diaphragm as the major filtration barrier. Junctional adhesion molecule 4 (JAM4) has been identified as a protein that interacts with membrane-associated guanyl kinase inverted (MAGI)-1 and is reported to be expressed on podocytes. To elucidate the role of JAM4 ... More
Role of membrane microdomains in PTH-mediated down-regulation of NaPi-IIa in opossum kidney cells.
AuthorsNashiki K, Taketani Y, Takeichi T, Sawada N, Yamamoto H, Ichikawa M, Arai H, Miyamoto K, Takeda E
JournalKidney Int
PubMed ID16105044
'Parathyroid hormone (PTH) rapidly down-regulates type IIa sodium-dependent phosphate transporter (NaPi-IIa) via an endocytic pathway. Since the relationship between PTH signaling and NaPi-IIa endocytosis has not been explored, we investigated the role of membrane microdomains in this process.' ... More
Ezrin mutants affecting dimerization and activation.
AuthorsChambers DN, Bretscher A,
JournalBiochemistry
PubMed ID15751968
ERM (ezrin/radixin/moesin) proteins provide a regulated linkage between membrane-associated proteins and the actin cytoskeleton. Previous work has shown that ezrin can exist in a dormant monomeric state in which the N-terminal FERM domain is tightly associated with the C-ERMAD (carboxyl-terminal ERM association domain), masking binding sites for at least some ... More
Ezrin as a prognostic indicator and its relationship to tumor characteristics in uveal malignant melanoma.
AuthorsMäkitie T, Carpén O, Vaheri A, Kivelä T,
JournalInvest Ophthalmol Vis Sci
PubMed ID11581181
Immunohistochemistry was used to investigate whether uveal malignant melanoma expresses ezrin, a protein involved in cell migration and cell recognition by acting as a linker between the plasma membrane and actin cytoskeleton. Also investigated was whether ezrin immunoreactivity correlates with survival prognosis. A monoclonal antibody, 3C12, that reacts with the ... More