Novel antibodies to synuclein show abundant striatal pathology in Lewy body diseases.
AuthorsDuda JE, Giasson BI, Mabon ME, Lee VM, Trojanowski JQ,
JournalAnn Neurol
PubMed ID12210791
'Intracytoplasmic inclusions composed of alpha-synuclein (alpha-syn) are characteristic of neurodegenerative Lewy body disorders. Using novel monoclonal antibodies raised against altered alpha-syn, we uncovered an unprecedented and extensive burden of alpha-syn pathology in the striatum of Lewy body disorders. The highest density of striatal pathology was observed in patients with a ... More