T-cell receptor ligation induces distinct signaling pathways in naive vs. antigen-experienced T cells.
AuthorsAdachi K, Davis MM
JournalProc Natl Acad Sci U S A
PubMed ID21205892
Naïve T lymphocytes display weaker and slower responses than antigen-experienced cells for reasons that are not well understood. Here we show that T-cell receptor (TCR) stimulation induces distinct ERK and p38 phosphorylation patterns in naïve and antigen-experienced human T cells, and that these contribute to the differential responses shown by ... More