Endosomal accumulation of GM1 ganglioside-bound amyloid beta-protein in neurons of aged monkey brains.
AuthorsKimura N, Yanagisawa K,
JournalNeuroreport
PubMed ID17921865
'We performed an immunohistochemical analysis of the GM1 ganglioside-bound amyloid beta-protein (GAbeta), an endogenous seed of Alzheimer amyloids, in sections of cerebral cortices of cynomolgus monkeys of different ages from 4 to 36 years old. Here, we show that neuronal GAbeta immunostaining significantly increases in the sections obtained from animals ... More
Expression of PCSK1 (PC1/3), PCSK2 (PC2) and PCSK3 (furin) in mouse small intestine.
AuthorsGagnon J, Mayne J, Mbikay M, Woulfe J, Chrétien M,
JournalRegul Pept
PubMed ID18706454
'The family of serine proteases known as the proprotein convertases subtilisin/kexin type (PCSK) is responsible for the cleavage and maturation of many precursor hormones. Over its three successive regions, the duodenum, the jejunum and the ileum, the small intestine (SI) expresses over 40 peptide hormones necessary for normal intestinal physiology. ... More