Interference with endothelial cell function by JG-03-14, an agent that binds to the colchicine site on microtubules.
AuthorsDalyot-Herman N, Delgado-Lopez F, Gewirtz DA, Gupton JT, Schwartz EL,
JournalBiochem Pharmacol
PubMed ID19576183
JG-03-14, a novel tetrasubstituted pyrrole with microtubule-depolymerizing and anti-proliferative activities, was tested for its effect on endothelial cell (EC) functions in vitro. JG-03-14 was a potent inhibitor of EC vessel-like tube formation on extracellular matrix (IC(50) of 40nM) and caused the involution of established vessels, potential anti-angiogenic and vascular-disrupting activities, ... More