Inhibitors of cathepsins B and L induce autophagy and cell death in neuroblastoma cells.
AuthorsCartledge DM, Colella R, Glazewski L, Lu G, Mason RW,
JournalInvest New Drugs
PubMed ID22549440
This study was designed to test the hypothesis that specific inhibition of cathepsins B and L will cause death of neuroblastoma cells. Five compounds that differ in mode and rate of inhibition of these two enzymes were all shown to cause neuroblastoma cell death. Efficacy of the different compounds was ... More