Cadherin-11 induces rheumatoid arthritis fibroblast-like synoviocytes to form lining layers in vitro.
AuthorsKiener HP, Lee DM, Agarwal SK, Brenner MB,
JournalAm J Pathol
PubMed ID16651616
The synovial lining of diarthrodial joints is composed of a condensed network of synoviocytes that form an intact layer via cell-to-cell contacts with significant intercellular matrix spaces. However, the molecular basis for synovial lining formation and its structural integrity has not been previously defined. In this study, using a three-dimensional ... More
Dynamic testicular adhesion junctions are immunologically unique. II. Localization of classic cadherins in rat testis.
AuthorsJohnson KJ, Boekelheide K,
JournalBiol Reprod
PubMed ID11906918
In the seminiferous epithelium, morphologically diverse junctions mediate inter-Sertoli and Sertoli-germ cell adhesive contact and likely transmit signals between contacting cells. Defining the molecular composition of testicular cell-cell junctions is an important step in determining their function. Proteins belonging to the cadherin superfamily are important mediators of cell-cell adhesion, as ... More