Lipocalin 2 diminishes invasiveness and metastasis of Ras-transformed cells.
AuthorsHanai J, Mammoto T, Seth P, Mori K, Karumanchi SA, Barasch J, Sukhatme VP,
JournalJ Biol Chem
PubMed ID15691834
'Lipocalin 2, an iron-siderophore-binding protein, converts embryonic kidney mesenchyme to epithelia. We found that lipocalin 2 could also convert 4T1-Ras-transformed mesenchymal tumor cells to an epithelial phenotype, increase E-cadherin expression, and suppress cell invasiveness in vitro and tumor growth and lung metastases in vivo. The Ras-MAPK pathway mediated the epithelial ... More