Aurora B expression correlates with aggressive behaviour in glioblastoma multiforme.
AuthorsZeng WF, Navaratne K, Prayson RA, Weil RJ,
JournalJ Clin Pathol
PubMed ID17264249
'Chromosomal abnormalities and genomic instability are common features of, and possible driving forces in, tumorigenesis. Recently, several mitotic proteins that are critical to proper chromosome segregation have been identified. Members of the Aurora kinase family have been identified as having important roles in mitosis; overexpression induces multicellularity and fosters polyploidy. ... More
Aurora B expression in post-puberal testicular germ cell tumours.
Aurora/Ipl1-related kinases are a conserved family of proteins that are essential for the regulation of chromosome segregation and cytokinesis during mitosis. Aberrant expression and activity of these kinases occur in a wide range of human tumours and have been implicated in mechanisms leading to mitotic spindle aberrations, aneuploidy, and genomic ... More