IRAK4 Polyclonal Antibody - Citations

IRAK4 Polyclonal Antibody - Citations

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Abstract
HIV induces both a down-regulation of IRAK-4 that impairs TLR signalling and an up-regulation of the antibiotic peptide dermcidin in monocytic cells.
AuthorsPathak S, De Souza GA, Salte T, Wiker HG, Asjö B,
JournalScand J Immunol
PubMed ID19703016
HIV-infected individuals have an increased risk of invasive bacterial infections, even at early clinical stages with relatively normal CD4(+) T-cell counts. The pathogenic mechanisms behind this are not fully understood. However, an increasing number of studies indicate that HIV may impair the innate immunity to bacteria by infecting key cells ... More