Axin is a scaffold protein in TGF-beta signaling that promotes degradation of Smad7 by Arkadia.
AuthorsLiu W, Rui H, Wang J, Lin S, He Y, Chen M, Li Q, Ye Z, Zhang S, Chan SC, Chen YG, Han J, Lin SC,
JournalEMBO J
PubMed ID16601693
TGF-beta signaling involves a wide array of signaling molecules and multiple controlling events. Scaffold proteins create a functional proximity of signaling molecules and control the specificity of signal transduction. While many components involved in the TGF-beta pathway have been elucidated, little is known about how those components are coordinated by ... More