CCN2 (connective tissue growth factor) promotes fibroblast adhesion to fibronectin.
AuthorsChen Y, Abraham DJ, Shi-Wen X, Pearson JD, Black CM, Lyons KM, Leask A,
JournalMol Biol Cell
PubMed ID15371538
In vivo, CCN2 (connective tissue growth factor) promotes angiogenesis, osteogenesis, tissue repair, and fibrosis, through largely unknown mechanisms. In vitro, CCN2 promotes cell adhesion in a variety of systems via integrins and heparin sulfate proteoglycans (HSPGs). However, the physiological relevance of CCN2-mediated cell adhesion is unknown. Here, we find that ... More