Macrophage migration inhibitory factor acts as a neurotrophin in the developing inner ear.
AuthorsBank LM, Bianchi LM, Ebisu F, Lerman-Sinkoff D, Smiley EC, Shen YC, Ramamurthy P, Thompson DL, Roth TM, Beck CR, Flynn M, Teller RS, Feng L, Llewellyn GN, Holmes B, Sharples C, Coutinho-Budd J, Linn SA, Chervenak AP, Dolan DF, Benson J, Kanicki A, Martin CA, Altschuler R, Koch AE, Koch AE, Jewett EM, Germiller JA, Barald KF,
JournalDevelopment
PubMed ID23172918
This study is the first to demonstrate that macrophage migration inhibitory factor (MIF), an immune system 'inflammatory' cytokine that is released by the developing otocyst, plays a role in regulating early innervation of the mouse and chick inner ear. We demonstrate that MIF is a major bioactive component of the ... More
The role of macrophage migration inhibitory factor in ocular surface disease pathogenesis after chemical burn in the murine eye.
AuthorsOh SY, Choi JS, Kim EJ, Chuck RS, Park CY,
JournalMol Vis
PubMed ID21152395
To evaluate the role of macrophage migration inhibitory factor (MIF) in the wound healing process following severe chemical burns to the ocular surface. Chemical burning of the ocular surface was induced in mice (C57BL/6) via the application of 0.1 M NaOH. Macrophage migration inhibitory factor (MIF), tumor necrosis factor-a (TNF-a), ... More