Ral GTPases regulate neurite branching through GAP-43 and the exocyst complex.
AuthorsLalli G, Hall A,
JournalJ Cell Biol
PubMed ID16330713
Neurite branching is essential for the establishment of appropriate neuronal connections during development and regeneration. We identify the small GTPase Ral as a mediator of neurite branching. Active Ral promotes neurite branching in cortical and sympathetic neurons, whereas Ral inhibition decreases laminin-induced branching. In addition, depletion of endogenous Ral by ... More